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Acetic Acid → 5-[2-[N-tert-butoxycarbonyl-2-(2-ethoxyphenoxy)ethylamino]propyl]indoline-7-carbonitrile

HRID 273855
ノート
印刷プレビュー

反応式

HRID 273855 の反応式
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:15][CH:16]([N:18]([CH2:26][CH2:27][O:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[O:35][CH2:36][CH3:37])[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH3:17])=[CH:10][C:11]=2[C:13]#[N:14])[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+].C(O)(=O)C>C(O)C>[C:22]([O:21][C:19]([N:18]([CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[O:35][CH2:36][CH3:37])[CH:16]([CH3:17])[CH2:15][C:9]1[CH:8]=[C:7]2[C:12](=[C:11]([C:13]#[N:14])[CH:10]=1)[NH:4][CH2:5][CH2:6]2)=[O:20])([CH3:25])([CH3:23])[CH3:24]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 200943581-acetyl-5-[2-[N-tert-butoxycarbonyl-2-(2-ethoxyphenoxy) ethylamino]propyl]indoline-7-carbonitrile

生成物 1

HCID 200943835-[2-[N-tert-butoxycarbonyl-2-(2-ethoxyphenoxy)ethylamino]propyl]indoline-7-carbonitrile収率 86.8%

試薬・触媒・溶媒 1

HCID 702Ethanol
溶媒

実験手順

To a solution of 1-acetyl-5-[2-[N-tert-butoxycarbonyl-2-(2-ethoxyphenoxy)ethylamino]propyl]indoline-7-carbonitrile (167 mg) in ethanol (2.2 ml) was added a 5N-sodium hydroxide solution (1.1 ml), and the mixture was reacted at room temperature for 2.5 hours. The reaction mixture was neutralized by adding acetic acid, and extracted with methylene chloride. The extract was washed with water and a saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 133 mg of 5-[2-[N-tert-butoxycarbonyl-2-(2-ethoxyphenoxy)ethylamino]propyl]indoline-7-carbonitrile as an oil.

後処理

  1. customthe mixture was reacted at room temperature for 2.5 hours
  2. extractionextracted with methylene chloride
  3. washThe extract was washed with water
  4. dry with materiala saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-0e78d18487e64198836ea2a8fa7e5f46
出典データセット
uspto-grants-1995_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05387603

反応ノート

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