HCID 20094378、化合物 → HCID 20094366、化合物
反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:16][CH:17]([N:19]([CH2:27][CH2:28][O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36]CC3C=CC=CC=3)[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH3:18])=[CH:10][C:11]=2[C:13]([NH2:15])=[O:14])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>CO.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:16][CH:17]([N:19]([CH2:27][CH2:28][O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[OH:36])[C:20]([O:22][C:23]([CH3:24])([CH3:26])[CH3:25])=[O:21])[CH3:18])=[CH:10][C:11]=2[C:13]([NH2:15])=[O:14])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]参加物
4
実験手順
To a solution of 1-acetyl-5-[2-[N-tert-butoxycarbonyl-2-(2-benzyloxyphenoxy)ethylamino]propyl]indoline-7-carboxamide (358 mg) in methanol (6 ml) was added 10% palladium on carbon (35 mg), and the mixture was stirred under an atmosphere of hydrogen at room temperature for 5 hours. After the catalyst was filtered off, and the filtrate was concentrated to dryness to give 273 mg of 1-acetyl-5-[2-[N-tert-butoxycarbonyl-2-(2-hydroxyphenoxy)ethylamino]propyl]indoline-7-carboxamide as an amorphous powder.