Sodium borohydride → (2-Trimethylsilyl-4-furyl)methanol

HRID 273967ノート

反応式

HRID 273967 の反応式
[CH3:1][Si:2]([CH3:11])([CH3:10])[C:3]1[O:4][CH:5]=[C:6]([CH:8]=[O:9])[CH:7]=1.[BH4-].[Na+]>CO>[OH:9][CH2:8][C:6]1[CH:7]=[C:3]([Si:2]([CH3:11])([CH3:10])[CH3:1])[O:4][CH:5]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 156632515-(Trimethylsilyl)furan-3-carbaldehyde

生成物 1

HCID 13333558(2-Trimethylsilyl-4-furyl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Trimethylsilyl-4-furaldehyde (1.57 g, 9.35 mmol) was added to a suspension of sodium borohydride (424 mg, 11.2 mmol) in methanol (10 ml) at 0° C. After 45 minutes, most of the methanol was evaporated and the residue taken up in ethyl ether. The ethyl ether extracts were combined, washed (water), dried (magnesium sulfate) and evaporated to dryness to give an oil, which was purified by flash chromatography on silica using 30% ethyl ether/hexane to give the title alcohol as a pale yellow oil.

後処理

  1. custommost of the methanol was evaporated
  2. washwashed (water)
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated to dryness
  5. customto give an oil, which
  6. customwas purified by flash chromatography on silica using 30% ethyl ether/hexane

出典と根拠

ORDレコード
ord-0381c8e967c94b669ec2927800657379
出典データセット
uspto-grants-1995_02
特許番号
US05387606

反応ノート

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