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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-gamma-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquino linepentanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 6456035 | — |
| 反応物 | alpha-(3-Chloro-2-methylpropyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile | HCID 19042099 | — |
| 生成物 | alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-gamma-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquino linepentanenitrile | HCID 20094567 | 17,563.4% |
反応手順
The procedure of Example 2 is repeated using 4.0 g of α-(3-chloro-2-methylpropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 3.5 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 0,985 g of the desired product as a yellow foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05387685 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-77e0ce66614b4cff85a6c75c9625f1b0 |
| 出典メモ | uspto-grants-1995_02 |