HRID273982

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6456035

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)

C11H16ClNO2

结构：COc1ccc(C(C#N)(CC(C)CCl)Sc2ccc(C)cc2)cc1OC

HCID19042099

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(C#N)(CC(C)CN2CCc3cc(OC)c(OC)cc3C2)Sc2ccc(C)cc2)cc1OC

HCID20094567

未命名化合物

收率 17,563.4%

PROCEDURE

实验过程

The procedure of Example 2 is repeated using 4.0 g of α-(3-chloro-2-methylpropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 3.5 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 0,985 g of the desired product as a yellow foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-77e0ce66614b4cff85a6c75c9625f1b0
来源数据集: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05387685
来源说明: uspto-grants-1995_02

反应 SMILES

Cl[CH2:2][CH:3]([CH3:26])[CH2:4][C:5]([S:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=1)([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)[C:6]#[N:7].Cl.[CH3:28][O:29][C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][C:39]=1[O:40][CH3:41])[CH2:36][NH:35][CH2:34][CH2:33]2>>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([C:5]([S:18][C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)([CH2:4][CH:3]([CH3:26])[CH2:2][N:35]2[CH2:34][CH2:33][C:32]3[C:37](=[CH:38][C:39]([O:40][CH3:41])=[C:30]([O:29][CH3:28])[CH:31]=3)[CH2:36]2)[C:6]#[N:7])[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]