Sodium Hydroxide → 4-[3-(1-Adamantyl)-4-methoxyphenylureido]benzoic acid

HRID 274031ノート

反応式

HRID 274031 の反応式
[OH-].[Na+].[C:3]12([C:13]3[CH:14]=[C:15]([NH:21][C:22](=[O:34])[NH:23][C:24]4[CH:33]=[CH:32][C:27]([C:28]([O:30]C)=[O:29])=[CH:26][CH:25]=4)[CH:16]=[CH:17][C:18]=3[O:19][CH3:20])[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][CH:5]([CH2:6]3)[CH2:4]1)[CH2:10]2>CO>[C:3]12([C:13]3[CH:14]=[C:15]([NH:21][C:22](=[O:34])[NH:23][C:24]4[CH:33]=[CH:32][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=4)[CH:16]=[CH:17][C:18]=3[O:19][CH3:20])[CH2:10][CH:9]3[CH2:11][CH:5]([CH2:6][CH:7]([CH2:8]3)[CH2:12]1)[CH2:4]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67714159Methyl 4-[3-(1-adamantyl)-4-methoxyphenylureido]benzoate

生成物 1

HCID 677141384-[3-(1-Adamantyl)-4-methoxyphenylureido]benzoic acid収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6 g (0.15 mol) of sodium hydroxide are added to a solution of 6.08 g (14 mmol) of methyl 4-[3-(1-adamantyl)-4-methoxyphenylureido]benzoate in 75 ml of methanol and the mixture is stirred at room temperature for 3 hours and then heated to re flux for 3.5 hours. The reaction mixture is evaporated, the residue is then taken up with 100 ml of water and the mixture is acidified to pH 1. The solid is filtered off, rinsed with water, dried and recrystallised in a tetrahydrofuran/hexane mixture to yield 2.78 g (87%) of 4-[3-(1-adamantyl)-4-methoxyphenylureido]benzoic acid, melting point 279°-282° C.

後処理

  1. temperatureheated
  2. customfor 3.5 hours
  3. customThe reaction mixture is evaporated
  4. filtrationThe solid is filtered off
  5. washrinsed with water
  6. customdried
  7. customrecrystallised in a tetrahydrofuran/hexane mixture

出典と根拠

ORDレコード
ord-358b17dc50e947e2b51994229b606628
出典データセット
uspto-grants-1995_02
特許番号
US05387594

反応ノート

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