HCID 20094804、化合物 → 3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-amine
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=O)[CH2:11][CH2:10][CH:9]([N+:14]([O-])=O)[CH2:8][C:7]=2[CH:17]=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][CH:9]([NH2:14])[CH2:8][C:7]=2[CH:17]=1参加物
5
実験手順
A solution of 2-methoxy-8-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one (0.20 g) in acetic acid (2 ml) was hydrogenated at 4 atm hydrogen atmosphere over 10% palladium on carbon (0.20 g). After removing the catalyst, the pH of the solution was adjusted to 12 with sodium hydroxide solution and the solution was extracted with ethyl acetate. The extract was washed with brine, dried over potassium carbonate, and evaporated in vacuo to give 3-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-amine (153 mg).
後処理
- customAfter removing the catalyst
- extractionthe solution was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over potassium carbonate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-4da40cfde7f443c5bfd2239d4256aa10
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387710
反応ノート
読み込み中…