Sodium Hydroxide → 4-Acetylamino-5-(3-methoxyphenyl)valeric acid

HRID 274076

反応式

HRID 274076 の反応式
[C:1]([NH:4][CH:5]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[CH2:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])(=[O:3])[CH3:2].[OH-].[Na+]>O1CCOCC1.Cl>[C:1]([NH:4][CH:5]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9])(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 20094840Tert-butyl 4-acetylamino-5-(3-methoxyphenyl)valerate

生成物 1

HCID 200947844-Acetylamino-5-(3-methoxyphenyl)valeric acid収率 86.3%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of tert-butyl 4-acetylamino-5-(3-methoxyphenyl)valerate (508 mg) in 1,4-dioxane (2 ml), 4N hydrogen chloride in 1,4-dioxane (4 ml) was added and the solution was stirred for 1 hour. The solution was poured into ice water (6 ml) and the pH of the solution was adjusted to 12 with sodium hydroxide solution. The solution was washed successively with diisopropyl ether and ethyl acetate and the pH of the solution was adjusted to 1 with 6N hydrochloric acid. The solution was extracted with ethyl acetate and the extract was washed with brine, dried over anhydrous sodium sulfate, and evaporated in vacuo to give 4-acetylamino-5-(3-methoxyphenyl)valeric acid (362 mg).

後処理

  1. washThe solution was washed successively with diisopropyl ether and ethyl acetate
  2. extractionThe solution was extracted with ethyl acetate
  3. washthe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6ed3ce07efd2419ca22ddb8ad687b278
出典データセット
uspto-grants-1995_02
特許番号
US05387710

関連ノート

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