Butylamine → N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

HRID 27409ノート

反応式

HRID 27409 の反応式
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[CH2:13]([NH2:17])[CH2:14][CH2:15][CH3:16]>CO>[CH2:13]([NH:17][C:2](=[O:1])[CH:6]([CH2:5][CH2:4][OH:3])[N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 8007ButylamineHCID 23342878HCID 23342878、化合物

生成物 1

HCID 23342869N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
65 °C

実験手順

10.14 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 50 ml of methanol and 8.78 g (0.12 mol) of n-butylamine are added to the solution. The reaction mixture is heated under reflux (65° C.) for 3 hours and then evaporated under a high vacuum. 12.3 g (yield: 85% of theory) of N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained in the form of a syrup.

後処理

  1. temperatureThe reaction mixture is heated
  2. customevaporated under a high vacuum

出典と根拠

ORDレコード
ord-fa4d7e580ea5470cbba88f220cd44dd1
出典データセット
uspto-grants-1980_09
特許番号
US04221789

反応ノート

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