Hydrochloric Acid → HCID 20092143、化合物

HRID 274186ノート

反応式

HRID 274186 の反応式
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Br[CH:25]([O:27][CH2:28][CH3:29])[CH3:26].[OH-].[Na+].Cl>O.C(O)C>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:26][CH2:25][O:27][CH2:28][CH3:29])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 145479151-Bromo-1-ethoxyethaneHCID 190469612-(4-Octyloxyphenyl)-5-hydroxy-6-fluoropyridine

生成物 1

HCID 20092143HCID 20092143、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 0.1 mol of 2C, 0.1 mol of 1-bromoethoxyethane, 0.1 mol of sodium hydroxide, 20 ml of ethanol and 50 ml of water is heated at the boil for 2 hours. The mixture is cooled, dilute hydrochloric acid is added, and the aqueous phase is extracted with dichloromethane. The solvent is removed under reduced pressure, and the residue is purified by column chromatography, giving the product 2-(4-octyloxyphenyl)-5-(2-ethoxyethoxy)-6-fluoropyridine.

後処理

  1. temperatureis heated at the boil for 2 hours
  2. temperatureThe mixture is cooled
  3. extractionthe aqueous phase is extracted with dichloromethane
  4. customThe solvent is removed under reduced pressure
  5. customthe residue is purified by column chromatography

出典と根拠

ORDレコード
ord-4e0bc83878c14500884c11b6594ab2ff
出典データセット
uspto-grants-1995_02
特許番号
US05389291

反応ノート

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