Methanol → HCID 178484885、化合物

HRID 274218

反応式

HRID 274218 の反応式
S(Cl)([Cl:3])=O.[CH3:5][NH:6][C@H:7]([C:15]([OH:17])=[O:16])[CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:14])[NH2:13].[CH3:18]O>>[ClH:3].[ClH:3].[CH3:18][O:16][C:15](=[O:17])[C@H:7]([CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:13])[NH2:14])[NH:6][CH3:5]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl Chloride2 回HCID 178484884HCID 178484884、化合物

生成物 1

HCID 178484885HCID 178484885、化合物

反応条件

温度
40 °C

実験手順

6.4 ml of thionyl chloride are added dropwise to a suspension of 15.06 g of N-methylarginine in 50 ml of absolute methanol at -10° C. The mixture is then allowed to come to room temperature, while stirring. Since starting material is still present after a reaction time of 17 hours, a further 9.6 ml of thionyl chloride are added in portions, the mixture is heated at 40° C. for 4 hours, the insoluble material is filtered off with suction and the filtrate is concentrated. The oily residue is dissolved in water, the insoluble material is filtered off and the product is freeze-dried.

後処理

  1. customto come to room temperature
  2. customafter a reaction time of 17 hours
  3. filtrationthe insoluble material is filtered off with suction
  4. concentrationthe filtrate is concentrated
  5. dissolutionThe oily residue is dissolved in water
  6. filtrationthe insoluble material is filtered off
  7. customthe product is freeze-dried

出典と根拠

ORDレコード
ord-b37a7ab4c7a04dd1a6fb0a747db9b236
出典データセット
uspto-grants-1995_02
特許番号
US05389614

関連ノート

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