4'-Chloropropiophenone → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 274341

反応式

HRID 274341 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[Br:12]Br>C(Cl)(Cl)Cl.[Cl-].[Al+3].[Cl-].[Cl-]>[Br:12][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:11]

参加物

5

反応物 2

HCID 226974'-ChloropropiophenoneHCID 24408Bromine

生成物 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-one収率 100%

試薬・触媒・溶媒 2

HCID 6451240Aluminum(III) Chloride触媒HCID 6212Chloroform溶媒

実験手順

4'-chloropropiophenone (39.6 g) and anhydrous aluminum chlorid (0.1 g) were dissolved in 100 ml of chloroform. To the resulting solution was protionwise added bromine (37.6 g) at a temperature of 30° to 35° C. The reaction mixture was stirred at room temperature for 30 minutes. Then nitrogen was blown into the reaction mixture to remove the formed hydrogen bromide therefrom. Thereafter, the solvent was distilled off under reduced pressure to give 2-bromo-4'-chloropropiophenone (58.1 g). mp 77.5°-79.5° C.

後処理

  1. customat a temperature of 30° to 35° C
  2. customto remove the formed hydrogen bromide
  3. distillationThereafter, the solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-e7e3e66bcd3044e68b419873ba254cb4
出典データセット
uspto-grants-1995_02
特許番号
US05389648

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