4-Hydroxy-3-methoxy-5-nitrobenzoic acid → 3,4-Dihydroxy-5-nitrobenzoic acid
反応式
[OH:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:14]C>Br>[OH:14][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[OH:1])[C:6]([OH:8])=[O:7]参加物
3
実験手順
A solution of 2.6 g of 4-hydroxy-3-methoxy-5-nitrobenzoic acid in 26 ml of constant-boiling hydrobromic acid is heated under reflux for 2 hours. After cooling the solvent is distilled in a water-jet vacuum. The crystalline residue is recrystallized from 50 ml of water at boiling temperature. There is obtained 3,4-dihydroxy-5-nitrobenzoic acid in the form of yellow crystals of m.p. 224°-226°.
後処理
- temperatureunder reflux for 2 hours
- temperatureAfter cooling the solvent
- distillationis distilled in a water-jet vacuum
- customThe crystalline residue is recrystallized from 50 ml of water
出典と根拠
- ORDレコード
- ord-b634ac88240545f0b27a7ebd5a90007c
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05389653
反応ノート
読み込み中…