Thioacetamide → 5-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide

HRID 274467

反応式

HRID 274467 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C>[BrH:1].[CH3:17][C:16]1[S:18][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=2)[N:19]=1

参加物

4

反応物 2

HCID 2723949ThioacetamideHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

生成物 1

HCID 214591025-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3.12 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 849.3 mg of thioacetamide are heated to boiling under reflux for 18 hours in 40 ml of ethanol. After cooling, the crystals are filtered under suction and recrystallized from methanol/isopropanol. There is obtained 5-(2-methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide of m.p. 280°-282°.

後処理

  1. temperatureare heated
  2. temperatureAfter cooling
  3. filtrationthe crystals are filtered under suction
  4. customrecrystallized from methanol/isopropanol

出典と根拠

ORDレコード
ord-a5b3873195ae4150b60aefa9620af38f
出典データセット
uspto-grants-1995_02
特許番号
US05389653

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