Thionicotinamide → 3-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol

HRID 274480

反応式

HRID 274480 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[C:16]([NH2:24])(=[S:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1>>[N+:11]([C:9]1[CH:10]=[C:5]([C:3]2[N:24]=[C:16]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[S:23][CH:2]=2)[CH:6]=[C:7]([OH:15])[C:8]=1[OH:14])([O-:13])=[O:12]

参加物

3

反応物 2

HCID 737155ThionicotinamideHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

生成物 1

HCID 214591993-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol

実験手順

A suspension of 2.91 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 1.31 g of thionicotinamide in 50 ml of alcohol and heated to boiling under reflux for 2 hours. After cooling to room temperature the crystals are filtered under suction and recrystallized from N,N-dimethylformamide/alcohol. There is obtained 3-nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol of m.p. 279°-281°.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. filtrationare filtered under suction
  4. customrecrystallized from N,N-dimethylformamide/alcohol

出典と根拠

ORDレコード
ord-9e82f967678f416c958045fed731d3fa
出典データセット
uspto-grants-1995_02
特許番号
US05389653

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