化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 4-Methyl-2-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2-Nitro-4-toluonitrile | HCID 96235 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 4-Methyl-2-nitrobenzoic acid | HCID 255027 | — |
反応手順
A mixed solution of 2-nitro-4-methylbenzonitrile (15.8 g) in a mixture of 65% sulfuric acid and acetic acid (150 ml) was heated under reflux for 17 hours. After concentration, the residue was poured into ice-water and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to dryness. Recrystallization of crystals from ether-hexane afforded colorless crystals (16.5 g, 94%), m.p. 156°-157° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05389641 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-3db63667ac724b178f81ecd389f3541d |
| 出典メモ | uspto-grants-1995_02 |