tert-Butanol → tert-Butyl 2-bromobenzoate
反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C1(N=C=NC2CCCCC2)CCCCC1.[C:26](O)([CH3:29])([CH3:28])[CH3:27]>CN(C)C1C=CN=CC=1.CCOCC>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:5]参加物
6
実験手順
A solution of o-bromobenzoic acid (1 g), N, N'-dicyclohexyl carbodiimide (1.129 g), t-butanol (405 mg) and 4-dimethylaminopyridine (61 mg) in dry ether (20 ml) was stirred at room temperature for 18 h. The resulting precipitate was filtered off and the filtrate evaporated to give a colourless solid which was triturated under petroleum ether (40°-600°) (20 ml) and filtered. The filtrate was evaporated to give a pale yellow oil (0,994 g). b.p. 80°-84°/0.35 mmHg.
後処理
- filtrationThe resulting precipitate was filtered off
- customthe filtrate evaporated
- customto give a colourless solid which
- customwas triturated under petroleum ether (40°-600°) (20 ml)
- filtrationfiltered
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-fe5be31c5b804969b55b6f3c62d68db1
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05389659
反応ノート
読み込み中…