Hydrochloric Acid → 5-Chloro-o-anisic acid

HRID 27465

反応式

HRID 27465 の反応式
Cl.[OH-:2].[Na+].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([O:14][CH3:15])=[C:9]([CH:13]=1)[C:10](Cl)=[O:11]>CC(C)=O.O>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([O:14][CH3:15])=[C:9]([CH:13]=1)[C:10]([OH:2])=[O:11]

参加物

6

反応物 3

HCID 313Hydrochloric Acid2 回HCID 14798Sodium HydroxideHCID 123841765-Chloro-2-methoxybenzoyl chloride

生成物 1

HCID 769705-Chloro-o-anisic acid

試薬・触媒・溶媒 2

HCID 180Acetone溶媒2 回HCID 962Water溶媒2 回

実験手順

2.5 g of hydrochloride were dissolved in 25 ml of acetone and 0.8 g of NaOH in 20 ml of water. To this solution, there were added 2 g of 5-chloro-2-methoxy-benzoyl chloride in 20 ml of acetone and the whole was stirred for 1 hour. Then, water and dilute hydrochloric acid were added and the product was recrystallized from methanol. The 4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-5-chloro-2-methoxy-benzoic acid so obtained was found to melt at 171°-173° C.

後処理

  1. customthe product was recrystallized from methanol

出典と根拠

ORDレコード
ord-7c74eb287f1e4f3aa2f705a2242fad10
出典データセット
uspto-grants-1980_09
特許番号
US04221815

関連ノート

読み込み中…