Hydrogen Bromide → HCID 178419246、化合物

反応式

[CH2:1]([CH2:4][SH:5])[CH2:2][NH2:3].Cl.Cl.O[CH2:9][C:10]1[N:11]=[CH:12][NH:13][C:14]=1[CH3:15].[BrH:16]>>[BrH:16].[BrH:16].[CH3:15][C:14]1[N:13]=[CH:12][NH:11][C:10]=1[CH2:9][S:5][CH2:4][CH2:1][CH2:2][NH2:3]

参加物

反応物 3

HCID 260Hydrogen Bromide

HCID 197870(3-Mercaptopropyl)ammonium chloride

HCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

生成物 1

HCID 178419246HCID 178419246、化合物

実験手順

A solution of homocysteamine hydrochloride (22.0 g.) and 4-hydroxymethyl-5-methylimidazole hydrochloride (25.6 g.) in aqueous hydrobromic acid (500 ml.) was heated under reflux for one hour. Concentration under reduced pressure, followed by recrystallisation from methanol-isopropyl alcohol afforded 4-methyl-5-[(3-aminopropyl)thiomethyl]-imidazole dihydrobromide (24.5 g.), m.p. 200.5°-202.5°.