Dimethylformamide → Methyl 3-benzyloxy-6-ethoxypicolinate

HRID 274881ノート

反応式

HRID 274881 の反応式
[CH2:1]([O:8][C:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:11][C:12]([OH:15])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20](Br)[CH3:21].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[CH2:1]([O:8][C:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:11][C:12]([O:15][CH2:20][CH3:21])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 178499129HCID 178499129、化合物

生成物 1

HCID 20088901Methyl 3-benzyloxy-6-ethoxypicolinate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5.0 g (19 mmol) of methyl 3-benzyloxy-6-hydroxypicolinate, 2.1 g (19 mmol) of ethyl bromide and 2.9 g (21 mmol) of potassium carbonate were added to 100 ml of DMF, and the resultant mixture was reacted at 80° C. for 5 hours. After the reaction, the reaction content was poured into water, and was extracted with ethyl acetate, washed with water, dried and concentrated. The residue thus obtained was purified by column chromatography to obtain an aimed compound.

後処理

  1. customAfter the reaction
  2. extractionwas extracted with ethyl acetate
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated
  6. customThe residue thus obtained
  7. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-6480cc74b20c4b78935446d42d05cad2
出典データセット
uspto-grants-1995_02
特許番号
US05391537

反応ノート

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