Ethylenediamine → N-(2-pyrimidylmethyl)ethylenediamine

反応式

[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[CH2:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1.OCC1N=CC=CN=1.S(Cl)(Cl)=O>>[N:8]1[CH:9]=[CH:10][CH:11]=[N:12][C:7]=1[CH2:6][NH:3][CH2:2][CH2:1][NH2:4]

参加物

反応物 4

HCID 3301Ethylenediamine

HCID 24386Thionyl Chloride

HCID 27630242-Pyrimidinemethanol

HCID 128773712-(Chloromethyl)pyrimidine

生成物 1

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

実験手順

By the procedure of Example 34, ethylenediamine is reacted with 2-chloromethylpyrimidine, prepared by treating 2-hydroxymethylpyrimidine with thionyl chloride, to give N-(2-pyrimidylmethyl)ethylenediamine.

後処理

customprepared

出典と根拠

ORDレコード: ord-c0e27ad025a84aa6ab26514471d15a49
出典データセット: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04221802

反応ノート

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