HCID 15767065、化合物 → 3-Pyridinecarboxylic acid, 2-(aminosulfonyl)-6-(trifluoromethyl)-, methyl ester
反応式
CC([NH:5][S:6]([C:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=[C:11]([C:19]([F:22])([F:21])[F:20])[N:10]=1)(=[O:8])=[O:7])(C)C>FC(F)(F)C(O)=O>[NH2:5][S:6]([C:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=[C:11]([C:19]([F:21])([F:22])[F:20])[N:10]=1)(=[O:7])=[O:8]参加物
3
実験手順
A solution of 0.95 g (2.79 mmol) of the product from Example 4 was stirred in 40 mL trifluoroacetic acid at room temperature overnight. The solution was evaporated to an oil which was triturated with ether to afford 0.46 g (58%) of a solid. m.p. 187°-188° C. 1H NMR (CDCl3) δ4.05 (3H, s), 5.5 (NH2), 7.95 (1H, d, J=8 Hz), 8.35 (1H, d, J=8 Hz); IR (mineral oil) 3390, 3280, 1725, 1340, 1140 cm-1.
後処理
- customThe solution was evaporated to an oil which
- customwas triturated with ether
出典と根拠
- ORDレコード
- ord-d5fec7e5ee7c49cb8d3303240aa31a4f
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05393734
反応ノート
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