Thionyl Chloride → 2-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

HRID 275260ノート

反応式

HRID 275260 の反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11])=[O:7].S(Cl)([Cl:24])=O>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([Cl:24])=[O:11])=[O:7]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

生成物 1

HCID 200876762-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

実験手順

A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.8 g) and thionyl chloride (10 ml) was heated at reflux for 3.5 hours. Excess reagent was removed by evaporation to yield 2-(3-trifluoromethylbenzoyl)nicotinoyl chloride as a red-brown gum (2 g) which was used in the next step without further purification.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. customExcess reagent was removed by evaporation

出典と根拠

ORDレコード
ord-3881d5926da84b78b87d9ae74e1a462f
出典データセット
uspto-grants-1995_02
特許番号
US05393730

反応ノート

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