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2-Thiophenesulfonyl chloride → 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Thiophenesulfonyl chloride | HCID 85518 | — |
| 反応物 | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride | HCID 131717719 | — |
| 生成物 | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid | HCID 21983467 | — |
反応手順
8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-[(2-thienylsulfonyl)amino]propyl hydrazide (30) was prepared from 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride (9), prepared as described above in Example 9, and 2-thiophenesulfonyl chloride in the same manner as described in Example 10 on a 1.9 mmol scale to yield 0.48 g (50%) of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05393747 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-d5b7721ad45546adafb93aa9c352e2b4 |
| 出典メモ | uspto-grants-1995_02 |