Triethylamine → 2-(trans-2-Hydroxycyclopentylamino)-1-methyl-7-(phenylmethyl)purin-6-one
反応式
Cl[C:2]1[N:3]([CH3:19])[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1.C(N(CC)CC)C.[NH2:27][C@@H:28]1[CH2:32][CH2:31][CH2:30][C@H:29]1[OH:33]>CC#N>[OH:33][C@@H:29]1[CH2:30][CH2:31][CH2:32][C@H:28]1[NH:27][C:2]1[N:3]([CH3:19])[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1参加物
5
実験手順
Heat at reflux for 2 days a mixture of 2-chloro-1-methyl-7-(phenylmethyl)purin-6-one (3.14 g=11.4 mmol), triethylamine (1.7 g=16.8 mmol), and (±)-trans-2-aminocyclopentanol (4.04 g=39.9 mmol) in CH3CN (150 ml). Collect the precipitate, wash with water, and dry to give the title compound, a solid, FAB MS: M+1=340.