Ethanol → n-(5-Amino-2-methoxyphenyl)acetamide
反応式
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:4]=1[NH2:5].[CH3:13][C:14](O)=[O:15].CC(OC(C)=O)=O.CCO>O.C1COCC1.O=[Pt]=O>[C:14]([NH:5][C:4]1[CH:6]=[C:7]([CH:8]=[CH:9][C:3]=1[O:2][CH3:1])[NH2:10])(=[O:15])[CH3:13]参加物
6
実験手順
2-Methoxy-5-nitroaniline was purchased and acetylated using HOAc/Ac2O in H2O/THF according to known procedures to make 2-methoxy-5-nitroacetanilide. This was reduced using catalytic hydrogenation (PtO2, H2, EtOH) to afford 3-acetamido-4-methoxyaniline which was reacted as described in Examples 1 and 2 to yield the desired glutarimide.
出典と根拠
- ORDレコード
- ord-a425c07c7b5d406baa6be5ac9f3e315a
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05393735
反応ノート
読み込み中…