Hydrogen iodide → 9-(1-Hydroxy-2-propyl)-6-iodopurine
反応式
[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2Cl)[CH3:4].[IH:15]>O>[OH:1][CH2:2][CH:3]([N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[I:15])[CH3:4]参加物
4
実験手順
9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%); mp=193°-194°; uv λmax 276 nm (H2O, pH 5.5).
後処理
- filtrationThe precipitate was filtered
- customneutralized with anhydrous sodium acetate at 5°
- washwashed with a little cold water (3 times)
- customRecrystallization from ethanol/H2O
- customgave colorless crystals
出典と根拠
- ORDレコード
- ord-a9c0746808a54bc09cad7a9b6fdf2446
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04221910
反応ノート
読み込み中…