Methyl iodide → N-(2-(4-Methoxyphenyl)ethyl)acetamide

HRID 275898

反応式

HRID 275898 の反応式
[C:1](=O)([O-])[O-].[K+].[K+].IC.[OH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:12][CH:11]=1>C(O)C.C(OCC)(=O)C>[CH3:1][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:14][CH:15]=1

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 121051N-Acetyltyramine

生成物 1

HCID 584258N-(2-(4-Methoxyphenyl)ethyl)acetamide収率 61%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Potassium carbonate (3.5 g, 25.5 mol) and iodomethane(2.0 ml, 31.9 mmol) was added to a solution of N-(4-hydroxyphenylethyl)acetamide (4.4 g, 24.6 mmol) in ethanol(2.4 ml), which was then refluxed for 12 hours. The resulting solid was filtered and washed with ethanol. The filtrate was concentrated to give oily residue, which was diluted with ethyl acetate and washed with water. The separated organic layer was concentrated and the resulting solid was suspended in ethylether, filtered, and dried to give 2.9 g of the titled compound.

後処理

  1. temperaturewas then refluxed for 12 hours
  2. filtrationThe resulting solid was filtered
  3. washwashed with ethanol
  4. concentrationThe filtrate was concentrated
  5. customto give oily residue, which
  6. washwashed with water
  7. concentrationThe separated organic layer was concentrated
  8. filtrationfiltered
  9. customdried

出典と根拠

ORDレコード
ord-5c11490e8aac4d3482257346829179eb
出典データセット
uspto-grants-2002_03
特許番号
US06352993B1

関連ノート

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