Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid
反応式
C([O:5][C:6](=[O:13])[C@@H:7]1[CH2:11][CH:10]([Cl:12])[CH2:9][NH:8]1)(C)(C)C.ClC1CN[C@H:17]([C:20]([OH:22])=O)C1.N1CCC[C@H]1C(O)=O.C(OC(=O)[C@@H]1CCCN1)(C)(C)C.C(CC(Cl)=[S:48])(=O)C.C(SCC(C)C(Cl)=O)(=O)C>>[Cl:12][CH:10]1[CH2:9][N:8]([C:20](=[O:22])[CH2:17][SH:48])[C:7]([C:6]([OH:5])=[O:13])=[CH:11]1参加物
7
反応物 6
生成物 1
実験手順
By substituting 4-chloro-L-proline tert-butyl ester [prepared from 4-chloro-L-proline by the procedure described in J. Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and 2-acetylthioacetyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1 and then submitting the product to the procedure of Example 2, 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid is obtained.
出典と根拠
- ORDレコード
- ord-8a895aa894ce4bd9bc2e173e11add461
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04221912
反応ノート
読み込み中…