benzyl N-[1-(hydroxymethyl)cyclohexyl]carbamate → (1-Aminocyclohexyl)methanol
反応式
C(OC([NH:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1参加物
4
実験手順
A slurry of 1-(benzyloxycarbonylamino)-1-(hydroxymethyl)cyclohexane (4.0 g, 15 mmol) and 10% Pd/C (0.40 g) in MeOH (75 ml) was stirred under H2 (1 atm.) for 1 h, then treated with Celite®. The resulting mixture was filtered and concentrated under reduced pressure to give 1-amino-1-(hydroxymethyl)cyclohexane.
後処理
- additiontreated with Celite®
- filtrationThe resulting mixture was filtered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b96e79cfef164e66b54433207daa4f14
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06353006B1
反応ノート
読み込み中…