Thionyl Chloride → N-cycloheptylmethyl-N-(2-chloroethyl)ammonium chloride

反応式

[CH:1]1([CH2:8][NH:9][CH2:10][CH2:11]O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:15]>>[Cl-:15].[CH:1]1([CH2:8][NH2+:9][CH2:10][CH2:11][Cl:15])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 18316190N-cycloheptylmethyl-N-(2-hydroxyethyl)amine

生成物 1

HCID 18316106N-cycloheptylmethyl-N-(2-chloroethyl)ammonium chloride

実験手順

2-Hydroxyethylamine was reacted with cycloheptylmethyl bromide according to Method B2a to give N-cycloheptylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cycloheptylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 2-methoxy-4-nitrophenyl isothiocyanate to give 2-(2-methoxy-4-nitrophenylimino)-3-(cycloheptylmethyl)-1,3-thiazolidine.

出典と根拠

ORDレコード: ord-691c7825460447b88e87e81f7046621e
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06353006B1

反応ノート

読み込み中…

参加物