2-Amino-2-phenylethan-1-ol → HCID 178428749、化合物

HRID 276495

反応式

HRID 276495 の反応式
[C:1]1([C@H:7]([NH2:10])[CH2:8]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].ClC[C@@H]([NH3+])C1C=CC=CC=1.[CH3:22][C:23]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:24]=1[N:32]=[C:33]=[S:34].[Cl-].ClC[C@@H]([NH3+])CC1C=CC=CC=1>>[CH3:22][C:23]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:24]=1[N:32]=[C:33]1[NH:10][C@@H:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][S:34]1

参加物

5

反応物 4

HCID 1347972-Amino-2-phenylethan-1-olHCID 1456212-Methyl-4-nitrophenyl isothiocyanateHCID 69994545(1S)-2-chloro-1-benzylethylammonium chlorideHCID 86590174(1S)-2-chloro-1-phenylethylammonium chloride

生成物 1

HCID 178428749HCID 178428749、化合物

実験手順

(1S)-1-Phenyl-2-hydroxyethylamine was converted to (1S)-2-chloro-1-phenylethylammonium chloride according to Method B7b. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-2-chloro-1-benzylethylammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-phenyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-phenyl-3-isobutyl-1,3-thiazolidine HCl salt.

出典と根拠

ORDレコード
ord-93849a706e05443aa0791ed8924f104a
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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