Ethanolamine → 5-Aza-12-oxadispiro[3.1.4.2]dodecane

HRID 276695

反応式

HRID 276695 の反応式
[NH2:1][C:2]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3]1.OC[C:12]1(N)[CH2:16][CH2:15][CH2:14]C1.OCCN.C1(=O)CCC1>>[CH2:14]1[C:15]2([O:9][CH2:7][C:2]3([CH2:3][CH2:4][CH2:5][CH2:6]3)[NH:1]2)[CH2:16][CH2:12]1

参加物

5

反応物 4

HCID 700EthanolamineHCID 2901CycloleucineHCID 14496CyclobutanoneHCID 663071-Aminocyclopentanemethanol

生成物 1

HCID 183159975-Aza-12-oxadispiro[3.1.4.2]dodecane

実験手順

1-Aminocyclopentanecarboxylic acid was converted to the methyl ester according to Method B1c, Step 1. The ester reduced to 1-hydroxymethylcyclopentanamine according to Method B1c, Step 2. The 2-hydroxyethylamine was reacted with cyclobutanone according to Method B4a, Step 1 to give 5-aza-12-oxadispiro[3.1.4.2]dodecane. The oxazolidine was reduced according to Method B4a, Step 2 to give 1-(cyclobutylamino)-1-(hydroxymethyl)cyclopentane. The substituted 2-hydroxyethylamine was reacted with SOCl2 according to Method B7b to 1-(cyclobutylamino)-1-(chloromethyl)cyclopentane. The 2-chloroethylamine was reacted with 2-methyl-4-nitrophenyl isocyanate according to Method C4a to afford 1-cyclobutyl-2-(2-methyl-4-nitrophenylimino)-3-oxa-1-azaspiro[4.4]nonane.

出典と根拠

ORDレコード
ord-b05a1cb0c8cf4b88846bcea17b61aa10
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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