Malonic Acid → 3-Carboxy-6-methylcoumarin
反応式
[CH3:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.[C:11](O)(=[O:16])[CH2:12][C:13]([OH:15])=[O:14].N1C=CC=CC=1.NC1C=CC=CC=1>C(O)C.O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:11](=[O:16])[C:12]([C:13]([OH:15])=[O:14])=[CH:7][C:6]=2[CH:9]=1参加物
7
反応条件
- 温度
- 40 °C
実験手順
2 g of 5-methylsalicylaldehyde (14.7 mmol), 3.06 g of malonic acid (29.4 mmol), 1.3 g of pyridine and 0.08 g of aniline are dissolved in a minimum amount of ethanol. The mixture is heated at 40° C. on a water bath for 6 h. Next, it is diluted with water, acidified and then extracted with ether. The solvent is removed by distillation under reduced pressure. The residue obtained is recrystallized from ethanol.
後処理
- extractionextracted with ether
- customThe solvent is removed by distillation under reduced pressure
- customThe residue obtained
- customis recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-f1dfcf20fe7d423885f3648f9289de6e
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06355658B1
反応ノート
読み込み中…