Dimethylformamide → HCID 10654815、化合物

HRID 277174ノート

反応式

HRID 277174 の反応式
C([Li])CCC.[CH3:6][C:7]1[C:12]2[CH:13]=[CH:14][O:15][C:11]=2[C:10]([CH3:16])=[CH:9][CH:8]=1.CN(C)[CH:19]=[O:20].C(OCC)(=O)C>O1CCCC1>[CH3:6][C:7]1[C:12]2[CH:13]=[C:14]([CH:19]=[O:20])[O:15][C:11]=2[C:10]([CH3:16])=[CH:9][CH:8]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 331094,7-DimethylbenzofuranHCID 178418339Butyllithium

生成物 1

HCID 10654815HCID 10654815、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

18.4 ml n-butyl lithium (1.56 M solution in hexane) was added to 50 ml solution of 3.5 g 4,7-dimethylbenzofuran in anhydrous tetrahydrofuran at −35° C. in a nitrogen atmosphere. After stirring for 15 minutes,5.6 ml N,N-dimethylformamide was added dropwise thereto, and the temperature was raised to room temperature. Ethyl acetate was added to the reaction mixture, and the organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resulting crude crystals were washed with n-hexane to give 2.3 g of 4,7-dimethylbenzofuran-2-carbaldehyde as apale yellow solid.

後処理

  1. washthe organic layer was washed with brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated
  4. washthe resulting crude crystals were washed with n-hexane

出典と根拠

ORDレコード
ord-c4d8e4f73b004d48b88619140d9445fc
出典データセット
uspto-grants-2002_03
特許番号
US06355669B1

反応ノート

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