Methyl iodide → 1-methyl-1H,4H,5H,6H,7H-imidazo[4,5-c]pyridine

反応式

[NH:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[N:3]=[CH:2]1.[CH3:10]I>>[CH3:10][N:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[N:3]=[CH:2]1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 178420865HCID 178420865、化合物

生成物 1

HCID 9290961-methyl-1H,4H,5H,6H,7H-imidazo[4,5-c]pyridine

実験手順

Operating as in Example 1, but starting from 4,5,6,7-tetrahydroimidazo-[4,5-c]-pyridine and methyl iodide, 1-Methyl-4,5,6,7-tetrahydroimidazo-[4,5-c]-pyridine is obtained as intermediate and successively reacted with methyl isothiocyanate to give 1-Methyl-5-(N-methylthiocarbamoyl)-4,5,6,7-tetrahydroimidazo-[4,5-c]-pyridine in a 78% yield, m.p. 238° C.

出典と根拠

ORDレコード: ord-f69abc026200451db69fe26f9ec86191
出典データセット: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04223146

反応ノート

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