Water → 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

HRID 27762

反応式

HRID 27762 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][C:5]([C:13]#[N:14])=[C:4]([CH3:15])[N:3]=1.[CH:16]([NH2:20])([CH2:18][CH3:19])[CH3:17].O>C(O)C>[C:13]([C:5]1[CH:6]=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:2]([NH:20][CH:16]([CH3:17])[CH2:18][CH3:19])=[N:3][C:4]=1[CH3:15])#[N:14]

参加物

5

反応物 3

HCID 962WaterHCID 24874Sec-ButylamineHCID 2758816Ethyl 2-chloro-5-cyano-6-methylnicotinate

生成物 1

HCID 867372195-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

22.4 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) of Example 1(b) are treated in 100 ml of ethanol with 15 g sec. butylamine at reflux temperature with stirring. After the addition of the amine is completed, the solution is poured into 200 ml of cold water, and the amino compound is filtered off. Yield 22 g (84%); m.p. 55°-57° C.

後処理

  1. temperatureat reflux temperature
  2. filtrationthe amino compound is filtered off

出典と根拠

ORDレコード
ord-8ae000ca848e414ea1ff080f0b71df04
出典データセット
uspto-grants-1980_09
特許番号
US04223142

関連ノート

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