Triethylamine → HCID 22625376、化合物

HRID 277646

反応式

HRID 277646 の反応式
[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]2[O:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.Cl.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.C(N(CC)CC)C>O1CCOCC1>[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][N:35]2[CH2:34][CH2:33][N:32]([C:25]3[CH:26]=[C:27]([O:30][CH3:31])[CH:28]=[CH:29][C:24]=3[O:23][CH3:22])[CH2:37][CH2:36]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 119882((p-(Benzyloxy)phenoxy)methyl)oxiraneHCID 13599003HCID 13599003、化合物

生成物 1

HCID 22625376HCID 22625376、化合物収率 33.9%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2.56 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane was dissolved in 100 ml of dioxane, and to this were added 2.95 g of 1-(2,5-dimethoxyphenyl)piperazine dihydrochloride and 3.5 ml of triethylamine and reaction and workup were carried out as in Example 1-A. The residue obtained was purified by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1) to give 1.62 g of brown oil.

後処理

  1. additionto this were added
  2. customThe residue obtained
  3. customwas purified by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1)

出典と根拠

ORDレコード
ord-74ab6cf6ea5342a989d4f284f57cbbbb
出典データセット
uspto-grants-2002_03
特許番号
US06358515B2

関連ノート

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