Water → Benzeneacetic acid, 4-(1,1-dimethylethyl)-

HRID 277720

反応式

HRID 277720 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].O>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 962WaterHCID 605629Methyl p-tert-butylphenylacetate

生成物 1

HCID 118343Benzeneacetic acid, 4-(1,1-dimethylethyl)-収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 4-t-butylphenylacetate (20 mmol) was dissolved in MeOH (160 mL) and treated with water (40 mL) and LiOH monohydrate (30 mmol). The reaction was allowed to stir at room temperature overnight. Volatiles were removed under reduced pressure, the remaining residue was diluted with water and neutralized to ph 4 with 1 N sulfuric acid. The resulting solids were filtered, washed with water and dried to leave 4-t-butylphenylacetic acid as an off-white solid (3.8 g, 99%).

後処理

  1. customVolatiles were removed under reduced pressure
  2. additionthe remaining residue was diluted with water
  3. filtrationThe resulting solids were filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-af08657aad9e4b77a676d6e70de6dc3d
出典データセット
uspto-grants-2002_03
特許番号
US06358945B1

関連ノート

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