(2R)-Oxiran-2-ylmethyl butanoate → HCID 54330421、化合物

HRID 277785

反応式

HRID 277785 の反応式
[C:1]1([CH2:7][O:8][C:9]([N:11]2[CH2:16][CH:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](OCC4C=CC=CC=4)=O)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([Li])CCC.[C:39]([O:44][CH2:45][C@@H:46]1[O:48]C1)(=[O:43])CCC>O1CCCC1>[C:1]1([CH2:7][O:8][C:9]([N:11]2[CH2:12][CH:13]=[C:14]([C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:24][C@H:45]([CH2:46][OH:48])[O:44][C:39]4=[O:43])=[CH:21][CH:22]=3)[CH2:15][CH2:16]2)=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 2724536(2R)-Oxiran-2-ylmethyl butanoateHCID 54271798HCID 54271798、化合物HCID 178418339Butyllithium

生成物 1

HCID 54330421HCID 54330421、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-78 °C

実験手順

A solution of 3,6-dihydro-4-[4-[[(phenylmethoxy)carbonyl]amino]phenyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester (EXAMPLE 17, Step 2, 0.500 g) in dry tetrahydrofuran (5.7 mL) at −78° C. under N2 is treated with n-butyllithium (0.73 mL, 1.6M in hexanes) dropwise over five minutes. The resulting mixture is stirred at −78° C. for 45 minutes and is then treated with (R)-(−)-glycidyl butyrate dropwise. The resulting solution is allowed to warm to ambient temperature over approximately 45 minutes and is stirred for an additional 20 hours, after which the reaction is quenched with saturated aqueous ammonium chloride (10 mL), diluted with water (20 mL) and extracted with ethyl acetate (2×15 mL). The combined organic phase is washed with saline (10 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the crude product which is chromatographed on silica gel (230-400 mesh, 40 g), eluting with methanol/methylene chloride (1/99). Pooling and concentration of those fractions with an Rf=0.37 by TLC (methanol/chloroform, 5/95) gives the title compound, mp 131.5-133.5° C.

後処理

  1. temperatureto warm to ambient temperature over approximately 45 minutes
  2. stirringis stirred for an additional 20 hours
  3. customafter which the reaction is quenched with saturated aqueous ammonium chloride (10 mL)
  4. additiondiluted with water (20 mL)
  5. extractionextracted with ethyl acetate (2×15 mL)
  6. washThe combined organic phase is washed with saline (10 mL)
  7. dry with materialdried over anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure
  9. customto give the crude product which
  10. customis chromatographed on silica gel (230-400 mesh, 40 g)
  11. washeluting with methanol/methylene chloride (1/99)

出典と根拠

ORDレコード
ord-42ee1b32a40943088d2cca5fa55b4207
出典データセット
uspto-grants-2002_03
特許番号
US06358942B1

関連ノート

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