Hydrochloric Acid → 3-(3-Bromophenyl)acrylic acid

HRID 2778

反応式

HRID 2778 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].Cl>N1CCCCC1.N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:11][C:12]([OH:14])=[O:13])[CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 765833-Bromobenzaldehyde

生成物 1

HCID 362513-(3-Bromophenyl)acrylic acid収率 94.4%

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

3-Bromobenzaldehyde (10.0 g, 54 mmol), malonic acid (10.1 g, 97 mmol) and piperidine (0.267 mL, 2.7 mmol) are treated with pyridine (30 mL) and heated at 100° C. for 3.5 h. The reaction mixture is cooled to room temperature, poured into 200 ml of 20% hydrochloric acid at 0° C.; the resultant precipitate is collected, washed with copious amounts of water and dried in a vacuum dessicator overnight to afford the title compound (11.64 g, 51 mmol).

後処理

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customthe resultant precipitate is collected
  3. washwashed with copious amounts of water
  4. customdried in a vacuum dessicator overnight

出典と根拠

ORDレコード
ord-d723d805d22049e68439ec36653ca220
出典データセット
uspto-grants-1998_03
特許番号
US05731315

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