Dimethylformamide → (2-(Pyrid-4-yl)-1H-benzimidazole-4-carbonyl)-(L)-valinamide

HRID 278032

反応式

HRID 278032 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[C:15]([C:16]([OH:18])=O)[C:9]=3[N:8]=2)=[CH:3][CH:2]=1.[B-](F)(F)(F)F.CCO[C:27]([C:29]([C:39]#[N:40])=NOC(N(C)C)=[N+](C)C)=O.[CH:41](N(C(C)C)CC)(C)C.C[N:51]([CH:53]=[O:54])C>>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[C:15]([C:16]([NH:40][C@H:39]([C:53]([NH2:51])=[O:54])[CH:29]([CH3:41])[CH3:27])=[O:18])[C:9]=3[N:8]=2)=[CH:5][CH:6]=1

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 112071702-Pyridin-4-yl-3H-benzoimidazole-4-carboxylic acid

生成物 1

HCID 11416447(2-(Pyrid-4-yl)-1H-benzimidazole-4-carbonyl)-(L)-valinamide

実験手順

120 mg (0.5 mmol) of 2-(pyrid-4-yl)-1H-benzimidazole-4-carboxylic acid (1d) and 76.4 mg (0.5 mmol) of H-(L)-valinamide were dissolved in 5 ml of DMF. 164 mg (0.5 mmol) of TOTU and 0.086 ml of diisopropylethylamine were added and the mixture was stirred at RT for 3 h. The precipitate was filtered off and the filtrate was concentrated. The residue was dissolved in ethyl acetate, the solution was washed with saturated sodium chloride solution, and the organic phase was dried using anhydride sodium sulfate and concentrated. Yield: 168 mg (99%). (M+H)+=338.2 (Cl+).

後処理

  1. filtrationThe precipitate was filtered off
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washthe solution was washed with saturated sodium chloride solution
  5. customthe organic phase was dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-cc209c226de84ecb942c3b52c5f48169
出典データセット
uspto-grants-2002_03
特許番号
US06358978B1

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