Hydrogen Bromide → Hydrogen Bromide
反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][CH:11]([NH2:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1.[BrH:19]>CC(O)=O>[NH2:18][CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:10][CH2:9][C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=1.[BrH:19]参加物
5
実験手順
A mixture of the product from Step C (920 mg), HOAc (2 mL) and 48% HBr (3 mL) was stirred while heating at reflux. After 2-3 hours, the solution was concentrated in vacuo to provide a pale beige sticky solid which was triturated with Et2O. Removal of residual solvents in vacuo provided the titled product hydrobromide as a pale beige froth.
後処理
- temperaturewhile heating
- temperatureat reflux
- concentrationthe solution was concentrated in vacuo
- customto provide a pale beige sticky solid which
- customwas triturated with Et2O
- customRemoval of residual solvents in vacuo
出典と根拠
- ORDレコード
- ord-0744501ef49e4ab5b29e01ccf689d3af
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06358985B1
反応ノート
読み込み中…