Sulfuric Acid → N-tert-Butyl-3,3-dimethyl-2-oxobutanamide

HRID 27838

反応式

HRID 27838 の反応式
[C:1]([C:7]#[N:8])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].S(=O)(=O)(O)[OH:10].[CH3:14][C:15](=[CH2:17])[CH3:16]>C(O)(=O)C>[C:15]([NH:8][C:7](=[O:10])[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])=[O:6])([CH3:16])([CH3:14])[CH3:17]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 945273,3-Dimethyl-2-oxobutanenitrile

生成物 1

HCID 13355144N-tert-Butyl-3,3-dimethyl-2-oxobutanamide収率 87%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

There were present in a stirrer apparatus protected against moisture 111 grams (1.0 mole) of pivaloyl cyanide, 150 grams (1.5 moles) of concentrated sulfuric acid and 150 ml of glacial acetic acid and there were led in during one hour under stirring at 0°-5° C.112 grams (2.0 moles) of isobutylene. Then the mixture was warmed up to room temperature and stirred further for 4 hours. Then the mixture was poured on 500 grams of ice and after thorough stirring the precipitated amide was filtered off with suction. After the drying in the vacuum drying cabinet, there were isolated 161 grams of analytically pure trimethyl pyruvic acid-N-t-butylamide which corresponds to a yield of 87% based on the acyl cyanide employed. The amide has a melting point of 65° C.

後処理

  1. customThere were present in a stirrer
  2. customwere led in during one hour
  3. stirringstirred further for 4 hours
  4. filtrationwas filtered off with suction
  5. customAfter the drying in the vacuum drying cabinet

出典と根拠

ORDレコード
ord-9689268751db44e2befdb5fba3d7f975
出典データセット
uspto-grants-1980_09
特許番号
US04224226

関連ノート

読み込み中…