Sodium Hydroxide → 5-(Pyridin-4-yl)thiophene-2-carboxylic acid

HRID 278555ノート

反応式

HRID 278555 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:11][C:10]([C:12]([O:14]C)=[O:13])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[S:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21928559Methyl 5-(pyridin-4-yl)thiophene-2-carboxylate

生成物 1

HCID 219285765-(Pyridin-4-yl)thiophene-2-carboxylic acid収率 94.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the obtained methyl 5-(4-pyridyl)-2-thiophenecarboxylate (410 mg) in ethanol (20 ml) was added 1 N sodium hydroxide solution (4 ml) and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated, and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound (363 mg).

後処理

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (4 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-b3bd37bc43a0402180e8c64f02ce3d2b
出典データセット
uspto-grants-2002_03
特許番号
US06359134B1

反応ノート

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