Sodium Hydroxide → 5-(Pyridin-4-yl)furan-2-carboxylic acid
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[O:11][C:10]([C:12]([O:14]C)=[O:13])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[O:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)=[CH:5][CH:6]=1参加物
4
実験手順
To a solution of the obtained methyl 5-(4-pyridyl)-2-furancarboxylate (100 mg) in ethanol (10 ml) was added 1 N sodium hydroxide solution (4 ml) and the solution was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound (59 mg).
後処理
- concentrationThe reaction solution was concentrated
- dissolutionthe residue was dissolved in water, to which
- additionwas added 1 N hydrochloric acid (4 ml)
- filtrationThe precipitate was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-8f3ae86932f34e06b1e09bc943875de0
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06359134B1
反応ノート
読み込み中…