Sodium Hydroxide → 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

HRID 278562

反応式

HRID 278562 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([O:14]CC)=[O:13])[N:11]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([OH:14])=[O:13])[N:11]=2)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 595483Ethyl 2-(pyridin-4-YL)thiazole-4-carboxylate

生成物 1

HCID 7160912-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid収率 95.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the obtained ethyl 2-(4-pyridyl)-4-thiazolecarboxylate (1.5 g) in ethanol (10 ml) was added 1 N sodium hydroxide solution (10 ml), and the solution was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in water, to which was added 1 N hydrochloric acid (10 ml). The precipitate was filtered, washed with water and dried to give the title compound (1.264 g).

後処理

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (10 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-e1ede9ccf4ad448984aee4eacd500246
出典データセット
uspto-grants-2002_03
特許番号
US06359134B1

関連ノート

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