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Hydrochloric Acid → 8-Hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester

HRID 27867
ノート
印刷プレビュー

反応式

HRID 27867 の反応式
[CH2:1]([O:3][C:4](=[O:15])[CH:5]=[C:6]([CH3:14])[CH:7]=[CH:8][CH:9]=[C:10]([CH:12]=[O:13])[CH3:11])[CH3:2].[BH4-].[Na+].Cl>C(O)C>[CH2:1]([O:3][C:4](=[O:15])[CH:5]=[C:6]([CH3:14])[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[CH2:12][OH:13])[CH3:2]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 54295620Ethyl 3,7-dimethyl-8-oxoocta-2,4,6-trienoate

生成物 1

HCID 539260748-Hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
10 °C

実験手順

36 g. of 7-formyl-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester are dissolved in 600 ml. of absolute ethanol. The solution is treated portionwise with 1.8 g. of sodium borohydride. The mixture is stirred for 2 hours at 10° C., then poured onto ice water and 3 n aqueous hydrochloric acid and extracted with ether. The ether extract is washed successively with water, a saturated aqueous sodium bicarbonate sodium and once more with water, dried over sodium sulfate and evaporated. There is obtained 8-hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester, which is processed further as follows:

後処理

  1. additionThe solution is treated portionwise with 1.8 g
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. washis washed successively with water
  5. dry with materiala saturated aqueous sodium bicarbonate sodium and once more with water, dried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-cc9bee96907546cab6b85a562360d591
出典データセット
uspto-grants-1980_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04224244

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート