Imidazole → 1-(4-Bromo-2-methyl-benzyl)-1H-imidazole

HRID 278788ノート

反応式

HRID 278788 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15]Br)=[C:11]([CH3:17])[CH:10]=1>CN(C=O)C>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[C:11]([CH3:17])[CH:10]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 24758Sodium hydrideHCID 225690184-Bromo-1-(bromomethyl)-2-methylbenzene2 回

生成物 1

HCID 225688221-(4-Bromo-2-methyl-benzyl)-1H-imidazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
90 °C

実験手順

A solution of imidazole (58.0 mg, 0.86 mmol) in 3 mL DMF was treated with NaH (20.0 mg, 0.86 mmol) and heated to 90° C. After lh a solution of 4-bromo-1-bromomethyl-2-methyl-benzene (Intermediate 138, 190.0 mg, 0.72 mmol) in 3 mL DMF was added and stirring at 90° C. continued for 1 hour. The solution was cooled to room temperature and concentrated under reduced pressure. The title compound, 160.0 mg (88%) was isolated by column chromatography (5% MeOH-EtOAc) as a colorless solid.

後処理

  1. additionwas added
  2. temperatureThe solution was cooled to room temperature
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d4caa756377f4bf3b57232151e120d3d
出典データセット
uspto-grants-2002_03
特許番号
US06359135B1

反応ノート

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