Water → 2,3,4,5,11,15b-hexahydro-1H-dibenz[3,4:6,7]azepino[1,2-a](1,4)diazepine
反応式
O=[C:2]1[CH2:8][CH2:7][N:6]2[C:9]3[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=3[CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:5]2[CH2:4][NH:3]1.O>C1COCC1>[CH2:4]1[NH:3][CH2:2][CH2:8][CH2:7][N:6]2[C:9]3[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=3[CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:5]12参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 7.5 g 2,3,4,5,11,15b-hexahydro-3-oxo-1H-dibenz[3,4:6,7]azepino[1,2-a](1,4)diazepine in 200 ml THF is added to a vigorously stirred suspension of 5 g LiALH4 in 400 ml dry THF. The mixture is boiled under reflux for 3 hours, after which it is cooled to about 0° C. 20 ml water is then added slowly to the mixture and the inorganic precipitate which forms is removed by filtration. The filtrate is evaporated to dryness, leaving a crystalline residue. Yield 5.3 g.